Photosynth from Microsoft appears to be a true game changer.
Assuming they can deal with scaling at a Google or YouTube pace (and it looks like they probably can), their approach to multi-resolution experiences and automated image linking, extraction, & assimilation, truly changes what images mean on the web.
You might think of what they are doing as creating the visual Semantic Web.
Powerful stuff.
Many thanks to ScuttleMonkey for his post to /.